McKenzie, Molly and Lian, Guang-Yu and Pennel, Kathryn A.F. and Quinn, Jean A. and Jamieson, Nigel B. and Edwards, Joanne (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10 (12): e32904. ISSN 2405-8440
AI Summary:
The NFB pathway plays a crucial role in colorectal cancer (CRC) initiation, progression, and therapy resistance. The canonical NFB pathway is driven by central kinase IKK, while the non-canonical NFB pathway is driven by kinases NIK and IKK.AI Topics:
The NFκB pathway, known as the central regulator of inflammation, has a well-established role in colorectal cancer (CRC) initiation, progression, and therapy resistance. Due to the pathway’s overarching roles in CRC, there have been efforts to characterise NFκB family members and target the pathway for therapeutic intervention. Initial research illustrated that the canonical NFκB pathway, driven by central kinase IKKβ, was a promising target for drug intervention. However, dose limiting toxicities and specificity concerns have resulted in failure of IKKβ inhibitors in clinical trials. The field has turned to look at targeting the less dominant kinase, IKKα, which along with NFκB inducing kinase (NIK), drives the lesser researched non-canonical NFκB pathway. However prognostic studies of the non-canonical pathway have produced conflicting results. There is emerging evidence that IKKα is involved in other signalling pathways, which lie outside of canonical and non-canonical NFκB signalling. Evidence suggests that some of these alternative pathways involve a truncated form of IKKα, and this may drive poor cancer-specific survival in CRC. This review aims to explore the multiple components of NFκB signalling, highlighting that NIK may be the central kinase for non-canonical NFκB signalling, and that IKKα is involved in novel pathways which promote CRC.
McKenzie, Molly
Author
Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377
Shamis, Suad A.K. and Quinn, Jean and Al-Badran, Sara and McKenzie, Molly and Hatthakarnkul, Phimmada and Lynch, Gerard and Lian, Guang-Yu and Numprasit, Warapan and Romics Jr, Laszlo and Andersen, Ditte and Mallon, Elizabeth and McMillan, Donald C. and Edwards, Joanne (2024) Elucidation of dysregulated pathways associated with hypoxia in oestrogen receptor-negative breast cancer. Cancer Medicine, 13 (23): e70274. ISSN 2045-7634
Galbraith, Norman J. and Quinn, Jean A. and Al-Badran, Sara Sf and Pennel, Kathryn A.F. and Hillson, Lily V.S. and Hatthakarnkul, Phimmada and McKenzie, Molly and Maka, Noori and Loi, Lynette and Frixou, Mikaela and Steele, Colin W. and Roxburgh, Campbell S. and Horgan, Paul G. and McMillan, Donald C. and Edwards, Joanne (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48: 102064. ISSN 1944-7124
See full publications listLian, Guang-Yu
Author
Shamis, Suad A.K. and Quinn, Jean and Al-Badran, Sara and McKenzie, Molly and Hatthakarnkul, Phimmada and Lynch, Gerard and Lian, Guang-Yu and Numprasit, Warapan and Romics Jr, Laszlo and Andersen, Ditte and Mallon, Elizabeth and McMillan, Donald C. and Edwards, Joanne (2024) Elucidation of dysregulated pathways associated with hypoxia in oestrogen receptor-negative breast cancer. Cancer Medicine, 13 (23): e70274. ISSN 2045-7634
McKenzie, Molly and Lian, Guang-Yu and Pennel, Kathryn A.F. and Quinn, Jean A. and Jamieson, Nigel B. and Edwards, Joanne (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10 (12): e32904. ISSN 2405-8440
Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966
See full publications listPennel, Kathryn A.F.
Author
Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377
Pennel, Kathryn and Kurniawan, Ahmad and Al-Badran, Sara Samir Foad and Schubert Santana, Leonor and Quinn, Jean and Nixon, Colin and Hatthakarnkul, Phimmada and Maka, Noori and Roxburgh, Campbell and McMillan, Donald and Edwards, Joanne (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14 (12): 1629. ISSN 2218-273X
Galbraith, Norman J. and Quinn, Jean A. and Al-Badran, Sara Sf and Pennel, Kathryn A.F. and Hillson, Lily V.S. and Hatthakarnkul, Phimmada and McKenzie, Molly and Maka, Noori and Loi, Lynette and Frixou, Mikaela and Steele, Colin W. and Roxburgh, Campbell S. and Horgan, Paul G. and McMillan, Donald C. and Edwards, Joanne (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48: 102064. ISSN 1944-7124
See full publications listQuinn, Jean A.
Author
Pennel, Kathryn and Kurniawan, Ahmad and Al-Badran, Sara Samir Foad and Schubert Santana, Leonor and Quinn, Jean and Nixon, Colin and Hatthakarnkul, Phimmada and Maka, Noori and Roxburgh, Campbell and McMillan, Donald and Edwards, Joanne (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14 (12): 1629. ISSN 2218-273X
Shamis, Suad A.K. and Quinn, Jean and Al-Badran, Sara and McKenzie, Molly and Hatthakarnkul, Phimmada and Lynch, Gerard and Lian, Guang-Yu and Numprasit, Warapan and Romics Jr, Laszlo and Andersen, Ditte and Mallon, Elizabeth and McMillan, Donald C. and Edwards, Joanne (2024) Elucidation of dysregulated pathways associated with hypoxia in oestrogen receptor-negative breast cancer. Cancer Medicine, 13 (23): e70274. ISSN 2045-7634
Galbraith, Norman J. and Quinn, Jean A. and Al-Badran, Sara Sf and Pennel, Kathryn A.F. and Hillson, Lily V.S. and Hatthakarnkul, Phimmada and McKenzie, Molly and Maka, Noori and Loi, Lynette and Frixou, Mikaela and Steele, Colin W. and Roxburgh, Campbell S. and Horgan, Paul G. and McMillan, Donald C. and Edwards, Joanne (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48: 102064. ISSN 1944-7124
See full publications listJamieson, Nigel B.
Author
MacDonald, Lucy and Elmesmari, Aziza and Somma, Domenico and Frew, Jack and Di Mario, Clara and Madhu, Roopa and Paoletti, Audrey and Simakou, Theodoros and Hardy, Olympia M. and Tolusso, Barbara and Campobasso, Denise and Perniola, Simone and Gessi, Marco and Gigante, Maria Rita and Petricca, Luca and Bruno, Dario and Coletto, Lavinia Agra and Benvenuto, Roberta and Isaacs, John D. and Filby, Andrew and McDonald, David and Sim, Jasmine P.X. and Jamieson, Nigel and Wei, Kevin and D’Agostino, Maria Antonietta and Millar, Neal L. and Milling, Simon and McSharry, Charles and Gremese, Elisa and Affleck, Karen and Baker, Kenneth F. and McInnes, Iain B. and Otto, Thomas D. and Korsunsky, Ilya and Alivernini, Stefano and Kurowska-Stolarska, Mariola (2024) Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis. Immunity, 57 (12). 2843-2862.e12. ISSN 1074-7613
Lucocq, James and Haugk, Beate and Parkinson, Daniel and Darne, Antony and Joseph, Nejo and Hawkyard, Jake and White, Steve and Mownah, Omar and Menon, Krishna and Furukawa, Takaki and Inoue, Yosuke and Hirose, Yuki and Sasahira, Naoki and Mittal, Anubhav and Samra, Jas and Sheen, Amy and Feretis, Michael and Balakrishnan, Anita and Ceresa, Carlo and Davidson, Brian and Pande, Rupaly and Dasari, Bobby V.M. and Tanno, Lulu and Karavias, Dimitrios and Helliwell, Jack and Young, Alistair and Nunes, Quentin and Urbonas, Tomas and Silva, Michael and Gordon-Weeks, Alex and Barrie, Jenifer and Gomez, Dhanny and van Laarhoven, Stijn and Nawara, Hossam and Doyle, Joseph and Bhogal, Ricky and Harrison, Ewen and Roalso, Marcus and Ciprani, Deborah and Aroori, Somaiah and Ratnayake, Bathiya and Koea, Jonathan and Capurso, Gabriele and Bellotti, Ruben and Stättner, Stefan and Alsaoudi, Tareq and Bhardwaj, Neil and Jeffery, Fraser and Connor, Saxon and Cameron, Andrew and Jamieson, Nigel and Roberts, Keith and Soreide, Kjetil and Gill, Anthony J. and Pandanaboyana, Sanjay (2024) Precursor epithelial subtypes of adenocarcinoma arising from intraductal papillary mucinous neoplasms (A-IPMN): clinicopathological features, recurrence and response to adjuvant chemotherapy. Annals of Surgical Oncology, 31 (10). pp. 7023-7032. ISSN 1068-9265
McKenzie, Molly and Lian, Guang-Yu and Pennel, Kathryn A.F. and Quinn, Jean A. and Jamieson, Nigel B. and Edwards, Joanne (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10 (12): e32904. ISSN 2405-8440
See full publications listEdwards, J.
Author
Thompson, Joshua J. and MacLeod, Nicholas and Will, Sarah and O'Rourke, Fraser and McGovern, Josh and Roxburgh, Campbell and Edwards, Joanne and Dolan, Ross D. and McMillan, Donald C. (2025) The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer. BMC Cancer, 25: 543. ISSN 1471-2407
Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377
Pennel, Kathryn and Kurniawan, Ahmad and Al-Badran, Sara Samir Foad and Schubert Santana, Leonor and Quinn, Jean and Nixon, Colin and Hatthakarnkul, Phimmada and Maka, Noori and Roxburgh, Campbell and McMillan, Donald and Edwards, Joanne (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14 (12): 1629. ISSN 2218-273X
See full publications listAvailable under License Creative Commons Attribution.
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