Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
AI Summary:
Adults with intellectual disabilities were more likely to die of cancer than the general population. Reasons for this may include later presentation, diagnosis so poorer outcomes, poorer treatment compliance or both.AI Topics:
Objective: To provide contemporary data on cancer mortality rates within the context of incidence in the population with intellectual disabilities.
Methods: Scotland’s 2011 Census was used to identify adults with intellectual disabilities and controls with records linked to the Scottish Cancer Registry and death certificate data (March 2011–December 2019). The control cohort without intellectual disabilities and/or autism were used for indirect standardisation and calculation of crude incident rates/crude mortality rates, and age–sex standardised incident rate ratios/standardised mortality ratios (SIR/SMR), with 95% CIs.
Results: Adults with intellectual disabilities were most likely diagnosed cancers of digestive, specifically colorectal (14.2%), lung (9.3%), breast (female 22.9%), body of the uterus (female 9.3%) and male genital organs (male 17.6%). Higher incident cancers included metastatic cancer of unknown primary origin (female SIR=1.70, male SIR=2.08), body of uterus (female SIR=1.63), ovarian (female SIR=1.59), kidney (female SIR=1.85) and testicular (male SIR=2.49). SMRs were higher, regardless of a higher, similar or lower incidence (female SMR=1.34, male SMR=1.07). Excess mortality risk was found for colorectal (total SMR=1.54, male SMR=1.59), kidney (total SMR=2.01 u, female SMR=2.85 u), female genital organs (SMR=2.34 (ovarian SMR=2.86 u, body of uterus SMR=2.11), breast (female SMR=1.58) and metastatic cancer of unknown primary origin (female SMR=2.50 u, male SMR=2.84).
Conclusions: Adults with intellectual disabilities were more likely to die of cancer than the general population. Reasons for this may include later presentation/diagnosis (so poorer outcomes), poorer treatment/compliance or both. Accessible public health approaches are important for people with intellectual disabilities, and healthcare professionals need to be aware of the different cancer experiences faced by this population.
Ward, Laura McKernan
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listCooper, Sally-Ann
Author
Dagnan, Dave and Thompson, Paul and Hastings, Richard P. and Hatton, Chris and Melville, Craig and Cooper, Sally-Ann and McMeekin, Nicola and Fulton, Lauren and Jones, Rob S.P. and McConnachie, Alex and Jahoda, Andrew (2024) The influence of therapy quality on outcomes from behavioural activation and guided self-help treatments for depression in adults with intellectual disabilities. British Journal of Clinical Psychology, 64 (2). pp. 139-147. ISSN 0144-6657
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listSosenko, Filip
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listMorrison, David
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listFleming, Michael
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listMcCowan, Colin
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listRobb, Katie
Author
Christie-de Jong, Floor and Eberhardt, Judith and Ling, Jonathan and Kotzur, Marie and Oyeniyi, Olugbenga Samuel and Nnyanzi, Lawrence and Kabuye, John and Kalemba, Martin and Robb, Kathryn A. (2024) The PROCAN-B Study Protocol: Early diagnosis of PROstate CANcer for Black men - a community-centred participatory approach in Scotland and the North-East of England. PLoS ONE, 19 (12): e0315288. ISSN 1932-6203
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listHanna, Catherine
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
Prowse, Sarah R. and Treweek, Shaun and Kiezebrink, Kirsty and Hanna, Catherine (2024) Evidencing the impacts of health research: Insights from trials reported in the 2018 Australian Engagement and Impact Assessment. Health Promotion Journal of Australia, 35 (2). pp. 423-432. ISSN 1036-1073
Lemmon, Elizabeth and Hanna, Catherine and Diernberger, Katharina and Paterson, Hugh M. and Wild, Sarah H. and Ennis, Holly and Hall, Peter S. (2024) Variation in colorectal cancer treatment and outcomes in Scotland: Real world evidence from national linked administrative health data. International Journal of Population Data Science, 9 (1): 2179. ISSN 2399-4908
See full publications listHughes-McCormack, Laura
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listDunn, Kirsty
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listConway, D.
Author
Serban, Stefan and Conway, David (2025) Sugar tax impact on oral health and the need to go further upstream. British Dental Journal, 238 (8). pp. 642-643. ISSN 0007-0610
Warner, Frances and Sherriff, Andrea and Culshaw, Shauna and Holliday, Richard and Ryan, Vicky and Conway, David I. (2024) Trends and socioeconomic inequalities in the dental attendance of adult smokers in Scotland from 2009 to 2019, a repeated cross-sectional study. BMC Public Health, 24 (1): 2156. ISSN 1471-2458
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
See full publications listHenderson, Angela
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listSmith, Gill
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listTruesdale, Maria
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
See full publications listCairns, Deborah
Author
Ward, Laura McKernan and Cooper, Sally-Ann and Sosenko, Filip and Morrison, David and Fleming, Michael and McCowan, Colin and Robb, Katie and Hanna, Catherine R. and Hughes-McCormack, Laura and Dunn, Kirsty and Conway, David and Henderson, Angela and Smith, Gill and Truesdale, Maria and Cairns, Deborah (2024) Population-based cancer incidence and mortality rates and ratios among adults with intellectual disabilities in Scotland: a retrospective cohort study with record linkage. BMJ Open, 14 (8): e084421. ISSN 2044-6055
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