Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
AI Summary:
The study examined trends in head and neck cancers (HNCs) in Scotland over 20 years. The results showed that overall HNC incidence remained relatively stable, but there were significant increases in oropharynx cancer (OPC) incidence rates.AI Topics:
Background:
Increasing incidence of head and neck cancers (HNCs), driven by rising rates of oropharynx cancer (OPC), has been recorded around the world. This study examined trends in HNC and subsites (oral cavity, oropharynx, and larynx cancers) in Scotland focusing on assessing whether the sociodemographic profile has changed over the past 20 years.
Methods:
Scottish Cancer Registry data (2001–2020) including European Age Standardised Rates of HNC and subsites were analysed in multivariate Poisson regression by age, sex, area-based socioeconomic status, and year of diagnosis (with interaction tests).
Results:
Overall HNC and oral cavity cancer (OCC) incidence remained relatively stable. OPC incidence rates increased by 78%, while larynx cancer incidence declined by 27%. Over time, there were marginal shifts to a slightly older age profile for HNC (p = 0.001) and OCC (p = 0.001), but no changes in OPC (p = 0.86) and larynx cancer (p = 0.29). No shift in the sex profile of HNC was observed except for minor increases in female OCC rates (p = 0.001), and the socioeconomic distribution remained unchanged across all HNC subsites.
Conclusions:
There have been no significant changes in the sociodemographic profile of HNC in Scotland over the last 20 years, despite the changing trends in HNCs with dramatically increasing incidence rates in OPC and reducing larynx cancer. This information can be used to target or stratify HNC prevention and control.
Smith, Craig D.L.
Author
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
Smith, Craig D.L. and McMahon, Alex D. and Lyall, Donald M. and Goulart, Mariel and Inman, Gareth and Ross, Al and Gormley, Mark and Dudding, Tom and Macfarlane, Gary J. and Robinson, Max and Richiardi, Lorenzo and Serraino, Diego and Polesel, Jerry and Canova, Cristina and Ahrens, Wolfgang and Healy, Claire M. and Lagiou, Pagona and Holcatova, Ivana and Alemany, Laia and Znoar, Ariana and Waterboer, Tim and Brennan, Paul and Virani, Shama and Conway, David I. (2024) Development and external validation of a head and neck cancer risk prediction model. Head and Neck, 46 (9). pp. 2261-2273. ISSN 1043-3074
See full publications listMcMahon, Alex
Author
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
Smith, Craig D.L. and McMahon, Alex D. and Lyall, Donald M. and Goulart, Mariel and Inman, Gareth and Ross, Al and Gormley, Mark and Dudding, Tom and Macfarlane, Gary J. and Robinson, Max and Richiardi, Lorenzo and Serraino, Diego and Polesel, Jerry and Canova, Cristina and Ahrens, Wolfgang and Healy, Claire M. and Lagiou, Pagona and Holcatova, Ivana and Alemany, Laia and Znoar, Ariana and Waterboer, Tim and Brennan, Paul and Virani, Shama and Conway, David I. (2024) Development and external validation of a head and neck cancer risk prediction model. Head and Neck, 46 (9). pp. 2261-2273. ISSN 1043-3074
Almutairi, Budur and Conway, D. and Ross, Alastair and Hattan, Mohammed and Almogren, Fayyad and McMahon, Alex (2024) Toothbrushing program in Saudi Arabia “TOPS”: A study protocol for a cluster randomized controlled trial in kindergartens, Riyadh. BMJ Open, 14 (8): e083504. ISSN 2044-6055
See full publications listPurkayastha, Mitana
Author
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
See full publications listCreaney, Grant
Author
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
Homer, Jarrod J. and Winter, Stuart C. and Abbey, Elizabeth C. and Aga, Hiba and Agrawal, Reshma and ap Dafydd, Derfel and Arunjit, Takhar and Axon, Patrick and Aynsley, Eleanor and Bagwan, Izhar N. and Batra, Arun and Begg, Donna and Bernstein, Jonathan M. and Betts, Guy and Bicknell, Colin and Bisase, Brian and Brady, Grainne C. and Brennan, Peter and Brunet, Aina and Bryant, Val and Cantwell, Linda and Chandra, Ashish and Chengot, Preetha and Chua, Melvin L.K. and Clarke, Peter and Clunie, Gemma and Coffey, Margaret and Conlon, Clare and Conway, David I. and Cook, Florence and Cooper, Matthew R. and Costello, Declan and Cosway, Ben and Cozens, Neil J.A. and Creaney, Grant and Gahir, Daljit K. and Damato, Stephen and Davies, Joe and Davies, Katharine S. and Dragan, Alina D. and Du, Yong and Edmond, Mark R.D. and Fedele, Stefano and Finze, Harriet and Fleming, Jason C. and Foran, Bernadette H. and Fordham, Beth and Foridi, Mohammed M.A.S. and Freeman, Lesley and Frew, Katherine E. and Gaitonde, Pallavi and Gallyer, Victoria and Gibb, Fraser W. and Gore, Sinclair M. and Gormley, Mark and Govender, Roganie and Greedy, J. and Urbano, Teresa Guerrero and Gujral, Dorothy and Hamilton, David W. and Hardman, John C. and Harrington, Kevin and Holmes, Samantha and Homer, Jarrod J. and Howland, Deborah and Humphris, Gerald and Hunter, Keith D. and Ingarfield, Kate and Irving, Richard and Isand, Kristina and Jain, Yatin and Jauhar, Sachin and Jawad, Sarra and Jenkins, Glyndwr W. and Kanatas, Anastasios and Keohane, Stephen and Kerawala, Cyrus J. and Keys, William and King, Emma V. and Kong, Anthony and Lalloo, Fiona and Laws, Kirsten and Leong, Samuel C. and Lester, Shane and Levy, Miles and Lingley, Ken and Madani, Gitta and Mani, Navin and Matteucci, Paolo L. and Mayland, Catriona R and McCaul, James and McCaul, Lorna K. and McDonnell, Pádraig and McPartlin, Andrew and Mercadante, Valeria and Merchant, Zoe and Mihai, Radu and Moonim, Mufaddal T. and Moore, John and Nankivell, Paul and Natu, Sonali and Nelson, A. and Nenclares, Pablo and Newbold, Kate and Newland, Carrie and Nicol, Ailsa J. and Nixon, Iain J. and Obholzer, Rupert and O'Hara, James T. and Orr, S. and Paleri, Vinidh and Palmer, James and Parry, Rachel S. and Paterson, Claire and Patterson, Gillian and Patterson, Joanne M. and Payne, Miranda and Pearson, L. and Poller, David N. and Pollock, Jonathan and Porter, Stephen Ross and Potter, Matthew and Prestwich, Robin J.D. and Price, Ruth and Ragbir, Mani and Ranka, Meena S. and Robinson, Max and Roe, Justin W.G. and Roques, Tom and Rovira, Aleix and Sainuddin, Sajid and Salmon, I.J. and Sandison, Ann and Scarsbrook, Andy and Schache, Andrew G. and Scott, A. and Sellstrom, Diane and Semple, Cherith J. and Shah, Jagrit and Sharma, Praveen and Shaw, Richard J. and Siddiq, Somiah and Silva, Priyamal and Simo, Ricard and Singh, Rabin P. and Smith, Maria and Smith, Rebekah and Smith, Toby Oliver and Sood, Sanjai and Stafford, Francis W. and Steven, Neil and Stewart, Kay and Stoner, Lisa and Sweeney, Steve and Sykes, Andrew and Taylor, Carly L. and Thavaraj, Selvam and Thomson, David J. and Thornton, Jane and Tolley, Neil S. and Turnbull, Nancy and Vaidyanathan, Sriram and Vassiliou, Leandros and Waas, John and Wade-McBane, Kelly and Wakefield, Donna and Ward, Amy and Warner, Laura and Watson, Laura-Jayne and Watts, H. and Wilson, Christina and Winter, Stuart C. and Wong, Winson and Yip, Chui-Yan and Yip, Kent (2024) Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition. Journal of Laryngology and Otology, 138 (S1). S1-S224. ISSN 0022-2151
See full publications listClements, Kelten
Author
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
See full publications listInman, Gareth
Author
White, Stephen E. and Schwartze, Tristin A. and Mukundan, Ananya and Schoenherr, Christina and Singh, Shashi P. and van Dinther, Maarten and Cunningham, Kyle T. and White, Madeleine P. J. and Campion, Tiffany and Pritchard, John and Hinck, Cynthia S. and ten Dijke, Peter and Inman, Gareth J. and Maizels, Rick M. and Hinck, Andrew P. (2025) TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts. Nature Communications, 16 (1): 1847. ISSN 2041-1723
Singh, Shashi P. and Smyth, Danielle J. and Cunningham, Kyle T. and Mukundan, Ananya and Byeon, Chang-Hyeock and Hinck, Cynthia S. and White, Madeleine P.J. and Ciancia, Claire and Wąsowska, Natalia and Sanders, Anna and Jin, Regina and White, Ruby F. and Lilla, Sergio and Zanivan, Sara and Schoenherr, Christina and Inman, Gareth and van Dinther, Maarten and ten Dijke, Peter and Hinck, Andrew P. and Maizels, Rick M. (2025) The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding. EMBO Reports, 26 (1). pp. 218-244. ISSN 1469-221X
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
See full publications listBhatti, Lesley A.
Author
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
See full publications listDouglas, Catriona M.
Author
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
See full publications listPaterson, Claire
Author
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
See full publications listConway, D.
Author
Serban, Stefan and Conway, David (2025) Sugar tax impact on oral health and the need to go further upstream. British Dental Journal, 238 (8). pp. 642-643. ISSN 0007-0610
Warner, Frances and Sherriff, Andrea and Culshaw, Shauna and Holliday, Richard and Ryan, Vicky and Conway, David I. (2024) Trends and socioeconomic inequalities in the dental attendance of adult smokers in Scotland from 2009 to 2019, a repeated cross-sectional study. BMC Public Health, 24 (1): 2156. ISSN 1471-2458
Smith, Craig D.L. and McMahon, Alex D. and Purkayastha, Mitana and Creaney, Grant and Clements, Kelten and Inman, Gareth J. and Bhatti, Lesley A. and Douglas, Catriona M. and Paterson, Claire and Conway, David I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020). BJC Reports, 2: 71. ISSN 2731-9377
See full publications listAvailable under License Creative Commons Attribution.
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