Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

Abstract

Steroids are a mainstay in the treatment of acute lymphoblastic leukaemia (ALL) in children and adolescents; however, their use can cause clinically significant steroid-related neuropsychiatric symptoms (SRNS). As current knowledge on SRNS during ALL treatment is limited, we mapped the phenotypes, occurrence and treatment strategies using a database created by the international Ponte di Legno Neurotoxicity Working Group including data on toxicity in the central nervous system (CNS) in patients treated with frontline ALL protocols between 2000 and 2017. Ninety-four of 1813 patients in the CNS toxicity database (5.2%) experienced clinically significant SRNS with two peaks: one during induction and one during intensification phase. Dexamethasone was implicated in 86% of SRNS episodes. The most common symptoms were psychosis (52%), agitation (44%) and aggression (31%). Pharmacological treatment, mainly antipsychotics and benzodiazepines, was given to 87% of patients while 38% were hospitalised due to their symptoms. Recurrence of symptoms was reported in 29% of patients and two previously healthy patients required ongoing pharmacological treatment at the last follow up. Awareness of SRNS during ALL treatment and recommendation on treatment strategies merit further studies and consensus.

People
Anastasopoulou, Stavroula
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Swann, Gemma
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Andres-Jensen, Liv
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Attarbaschi, Andishe
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Barzilai-Birenboim, Shlomit
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Erdelyi, Daniel J.
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Escherich, Gabriele
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Hamadeh, Lina
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Harila, Arja
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Lopez-Lopez, Elixabet
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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McGowan, Sheena
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Möricke, Anja
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Putti, Caterina
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Sagi, Judit C.
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Schmiegelow, Kjeld
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Ullrich, Nicole J.
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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van der Sluis, Inge M.
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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ul-Ain Wahid, Qurat
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Winick, Naomi
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Sramkova, Lucie
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Zalcberg, Yair
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Zapotocka, Ester
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Bhojwani, Deepa
Author

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Halsey, Christina
Author

Samarakoon, Youhan and Yelland, Tamas and Garcia-Gonzalez, Esther and Justo-Junior, Amauri da Silva and Mahmood, Mahnoor and Manoharan, Anand and Patterson, Shaun and Serafin, Valentina and Gammage, Payam A. and Marmiroli, Sandra and Halsey, Christina and Ismail, Shehab and Roberts, Edward W. (2025) UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia. Life Science Alliance, 8 (3): e202403066. ISSN 2575-1077

Apps, John and Halsey, Christina and Pritchard Jones, Kathy and Atun, Rifat and Shanmugavadivel, Dhurgshaarna and Oliver, Kathy and Vedhara, Kavita and Liu, JoFen and Ball-Gamble, Ashley and Ranasinghe, Neil and Polanco, Angela and Adamski, Jenny and Green, Adam and Walker, David A. (2024) A review calling for research directed at early detection of childhood cancers: the clinical, scientific, and economic arguments for population screening and surveillance. EJC Paediatric Oncology, 4: 100191. ISSN 2772-610X

Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205 (4). pp. 1450-1459. ISSN 0007-1048

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Title:
Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study
Creators:
Anastasopoulou, Stavroula and Swann, Gemma and Andres-Jensen, Liv and Attarbaschi, Andishe and Barzilai-Birenboim, Shlomit and Erdelyi, Daniel J. and Escherich, Gabriele and Hamadeh, Lina and Harila, Arja and Lopez-Lopez, Elixabet and McGowan, Sheena and Möricke, Anja and Putti, Caterina and Sagi, Judit C. and Schmiegelow, Kjeld and Ullrich, Nicole J. and van der Sluis, Inge M. and ul-Ain Wahid, Qurat and Winick, Naomi and Sramkova, Lucie and Zalcberg, Yair and Zapotocka, Ester and Bhojwani, Deepa and Halsey, Christina
Identification Number:
10.1111/bjh.19610
Date:
October 2024
Divisions:
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Publisher:
Wiley
Additional Information:
This study was supported by funding from Children with Cancer UK (2014/170) (CH), Glasgow Children’s Hospital Charity (GCHC/PSG/2016/11) (CH), Schiehallion Childrens Cancer and Leukaemia Fund (CH, QW), Cancer Research UK (Programme Foundation Award) (DRCPFA-Nov21\100001) (CH), CRUK Scotland Centre (CTRQQR-2021\100006) (CH), MH CZ – DRO Motol University Hospital, Prague, Czech Republic 00064203 (LS), and the Swedish Childhood Cancer Fund (TJ2020-0082, TJ2019-0031) (SA).
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URI:
https://pub.demo35.eprints-hosting.org/id/eprint/135
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
Date Deposited:
11 Jun 2025 16:35
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37
Last Modified:
12 Jun 2025 12:08
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