Wilson, Matthew R. and Cwynarski, Kate and Eyre, Toby A. and Smith, Jeffery and Chaganti, Sridhar and Fox, Christopher P. and McKay, Pamela (2024) Central nervous system prophylaxis in large B‐cell lymphoma: A British Society for Haematology Good Practice Paper. British Journal of Haematology, 205 (6). pp. 2198-2205. ISSN 0007-1048

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Abstract

Summary:
This Good Practice Paper provides recommendations for the baseline investigation, risk stratification and use of prophylactic interventions for patients with large B-cell lymphoma at risk of central nervous system relapse. Recent evidence which has questioned the role of high-dose methotrexate in this clinical scenario is discussed in detail.

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