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Wilson, Matthew R. and Cwynarski, Kate and Eyre, Toby A. and Smith, Jeffery and Chaganti, Sridhar and Fox, Christopher P. and McKay, Pamela (2024) Central nervous system prophylaxis in large B‐cell lymphoma: A British Society for Haematology Good Practice Paper. British Journal of Haematology, 205 (6). pp. 2198-2205. ISSN 0007-1048

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This Good Practice Paper provides recommendations for the diagnosis and treatment of patients with large B-cell lymphoma at risk of central nervous system relapse.

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Abstract

Summary:
This Good Practice Paper provides recommendations for the baseline investigation, risk stratification and use of prophylactic interventions for patients with large B-cell lymphoma at risk of central nervous system relapse. Recent evidence which has questioned the role of high-dose methotrexate in this clinical scenario is discussed in detail.

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Wilson, Matthew R.

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Publications

Wilson, Matthew R. and Kirkwood, Amy A. and Wong Doo, Nicole and Soussain, Carole and Choquet, Sylvain and Lees, Charlotte and Fox, Christopher and Preston, Gavin and Ahearne, Matthew and Strüßmann, Tim and Clavert, Aline and Rusconi, Chiara and Ku, Matthew and Khwaja, Jahanzaib and Narkhede, Mayur and Lewis, Katharine and Durot, Eric and Smith, Jeffery and Renaud, Loic and J._M. Ferreri, Andrés and el‐Galaly, Tarec and Cwynarski, Kate and McKay, Pam and Eyre, Toby A. (2024) Dosage of high‐dose methotrexate as CNS prophylaxis in DLBCL: A detailed analysis of toxicity and impact on CNS relapse. American Journal of Hematology, 99 (2). E46-E50. ISSN 0361-8609