Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
AI Summary:
Early-phase trials of venetoclax in children and teenagers with leukaemia have yielded promising results. The study reports a cohort of 41 children treated with venetoclax, demonstrating complete remission in 43.6% of patients.AI Topics:
Early-phase trials of venetoclax in children and teenagers/young adults with leukaemia have yielded promising results, but there remains a paucity of real-world data. To address this, we report a cohort of 41 children treated with venetoclax for a range of haematological malignancies, demonstrating complete remission in 43.6%, with most achieving minimal residual disease (MRD) negativity. Venetoclax was particularly effective as a bridge to transplant, with bridging successful in 75% of patients. Patients with MRD <1% at initiation of venetoclax were more likely to achieve MRD negativity (81.8% vs. 34.5%, p = 0.007) and had improved overall survival (54.5% vs. 17.9%, p = 0.004).
Wilson, Abbie
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listMoussa, Ahmed
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listTrinquand, Amélie
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listMalone, Andrea
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listTewari, Sanjay
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listCalvert, Richard
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listPatrick, Katharine
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listNicholson, Emma
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listSmith, Katy
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listGrandage, Victoria
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listBaird, Susan
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listGeorge, Lindsay
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listQureshi, Amrana
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listBorg, Albert
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listGibson, Brenda
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listPatel, Pritesh
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listBartram, Jack
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listSamrin, Lamia
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listO'Connor, David
Author
Wilson, Abbie and Moussa, Ahmed and Trinquand, Amélie and Malone, Andrea and Tewari, Sanjay and Calvert, Richard and Patrick, Katharine and Nicholson, Emma and Smith, Katy and Grandage, Victoria and Baird, Susan and George, Lindsay and Qureshi, Amrana and Borg, Albert and Gibson, Brenda and Patel, Pritesh and Bartram, Jack and Samrin, Lamia and O'Connor, David (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205 (6). pp. 2355-2362. ISSN 0007-1048
See full publications listRestricted to Repository staff only until 26 September 2025.
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